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KMID : 1134120200230010100
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Journal of Breast Cancer
2020 Volume.23 No. 1 p.100 ~ p.106
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Acute Lymphoblastic Leukemia in a Patient Treated with Letrozole and Palbociclib
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Park Jin-Hyun
Park Hyun-Kyung
Kim Ki-Hwan
Kim Jin-Soo
Choi In-Sil
Roh Eun-Youn
Kim Ji-Eun
Chang Mee-Soo
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Abstract
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Palbociclib, in conjunction with endocrine therapy, has been approved for the treatment of patients with advanced breast cancer. The common hematological toxicities associated with palbociclib are leukopenia and neutropenia. However, hematological malignancies have not been reported for palbociclib treatment. Here, for the first time, we present a case of acute lymphoblastic leukemia that was diagnosed in a patient undergoing treatment with letrozole and palbociclib for metastatic breast cancer. This case emphasizes the need for long term follow up of patients treated with palbociclib.
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KEYWORD
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Adverse effects, Breast neoplasms, Hematologic neoplasms, Palbociclib, Precursor cell lymphoblastic leukemia-lymphoma
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